The Gln3 Transcriptional Regulator of Saccharomyces cerevisiae Manifests Prion-Like Properties upon Overproduction.
Identifieur interne : 000206 ( Main/Exploration ); précédent : 000205; suivant : 000207The Gln3 Transcriptional Regulator of Saccharomyces cerevisiae Manifests Prion-Like Properties upon Overproduction.
Auteurs : K S Antonets [Russie] ; M V Belousov [Russie] ; M E Belousova [Russie] ; A A Nizhnikov [Russie]Source :
- Biochemistry. Biokhimiia [ 1608-3040 ] ; 2019.
Descripteurs français
- KwdFr :
- Agrégats de protéines (physiologie), Facteurs de transcription (génétique), Facteurs de transcription (métabolisme), Microscopie confocale (MeSH), Métallothionéine (génétique), Prions (métabolisme), Protéines de Saccharomyces cerevisiae (génétique), Protéines de Saccharomyces cerevisiae (métabolisme), Résistance des champignons aux médicaments (effets des médicaments et des substances chimiques), Saccharomyces cerevisiae (métabolisme), Sirolimus (pharmacologie).
- MESH :
- effets des médicaments et des substances chimiques : Résistance des champignons aux médicaments.
- génétique : Facteurs de transcription, Métallothionéine, Protéines de Saccharomyces cerevisiae.
- métabolisme : Facteurs de transcription, Prions, Protéines de Saccharomyces cerevisiae, Saccharomyces cerevisiae.
- pharmacologie : Sirolimus.
- physiologie : Agrégats de protéines.
- Microscopie confocale.
English descriptors
- KwdEn :
- Drug Resistance, Fungal (drug effects), Metallothionein (genetics), Microscopy, Confocal (MeSH), Prions (metabolism), Protein Aggregates (physiology), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae Proteins (genetics), Saccharomyces cerevisiae Proteins (metabolism), Sirolimus (pharmacology), Transcription Factors (genetics), Transcription Factors (metabolism).
- MESH :
- chemical , genetics : Metallothionein, Saccharomyces cerevisiae Proteins, Transcription Factors.
- drug effects : Drug Resistance, Fungal.
- chemical , metabolism : Prions, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Transcription Factors.
- chemical , pharmacology : Sirolimus.
- chemical , physiology : Protein Aggregates.
- Microscopy, Confocal.
Abstract
Prions are proteins that can exist under the same conditions in two or more conformations, at least one of them is infectious. Usually, acquisition of infectious prion conformation is associated with the formation of amyloids - protein aggregates with a characteristic spatial structure. About 10 prions have been identified in the yeast Saccharomyces cerevisiae. The Gln3 protein, which is one of the key regulators of nitrogen metabolism in S. cerevisiae, contains an amyloidogenic region manifesting prion-like properties. The prion properties of the full-length Gln3 have not been studied. We have found that the amyloidogenic region of Gln3 acts as a template and initiates aggregation of the full-length Gln3 in the presence of the [PIN+] prion when Gln3 is overexpressed. Full-length Gln3 in its aggregated form manifests prion-like properties, including infectivity and dependence on the anti-prion agents; however, unlike other known yeast prions, prion-like state of Gln3 is observed only upon the protein overproduction. Here, we suggest the term "conditional prions" for proteins, whose prion state is maintained exclusively under non-physiological conditions.
DOI: 10.1134/S0006297919040126
PubMed: 31228936
Affiliations:
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Regulator of Saccharomyces cerevisiae Manifests Prion-Like Properties upon Overproduction.</title><author><name sortKey="Antonets, K S" sort="Antonets, K S" uniqKey="Antonets K" first="K S" last="Antonets">K S Antonets</name><affiliation wicri:level="1"><nlm:affiliation>St. Petersburg State University, St. Petersburg, 199034, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>St. Petersburg State University, St. Petersburg, 199034</wicri:regionArea><wicri:noRegion>199034</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>All-Russia Research Institute for Agricultural Microbiology, St. Petersburg, 196608, Pushkin, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>All-Russia Research Institute for Agricultural Microbiology, St. Petersburg, 196608, Pushkin</wicri:regionArea><wicri:noRegion>Pushkin</wicri:noRegion></affiliation></author><author><name sortKey="Belousov, M V" sort="Belousov, M V" uniqKey="Belousov M" first="M V" last="Belousov">M V Belousov</name><affiliation wicri:level="1"><nlm:affiliation>St. Petersburg State University, St. Petersburg, 199034, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>St. Petersburg State University, St. Petersburg, 199034</wicri:regionArea><wicri:noRegion>199034</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>All-Russia Research Institute for Agricultural Microbiology, St. Petersburg, 196608, Pushkin, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>All-Russia Research Institute for Agricultural Microbiology, St. Petersburg, 196608, Pushkin</wicri:regionArea><wicri:noRegion>Pushkin</wicri:noRegion></affiliation></author><author><name sortKey="Belousova, M E" sort="Belousova, M E" uniqKey="Belousova M" first="M E" last="Belousova">M E Belousova</name><affiliation wicri:level="1"><nlm:affiliation>All-Russia Research Institute for Agricultural Microbiology, St. Petersburg, 196608, Pushkin, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>All-Russia Research Institute for Agricultural Microbiology, St. Petersburg, 196608, Pushkin</wicri:regionArea><wicri:noRegion>Pushkin</wicri:noRegion></affiliation></author><author><name sortKey="Nizhnikov, A A" sort="Nizhnikov, A A" uniqKey="Nizhnikov A" first="A A" last="Nizhnikov">A A Nizhnikov</name><affiliation wicri:level="1"><nlm:affiliation>St. Petersburg State University, St. Petersburg, 199034, Russia. ant.nizhnikov@gmail.com.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>St. Petersburg State University, St. Petersburg, 199034</wicri:regionArea><wicri:noRegion>199034</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>All-Russia Research Institute for Agricultural Microbiology, St. Petersburg, 196608, Pushkin, Russia.</nlm:affiliation><country 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Biokhimiia</title><idno type="eISSN">1608-3040</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Drug Resistance, Fungal (drug effects)</term><term>Metallothionein (genetics)</term><term>Microscopy, Confocal (MeSH)</term><term>Prions (metabolism)</term><term>Protein Aggregates (physiology)</term><term>Saccharomyces cerevisiae (metabolism)</term><term>Saccharomyces cerevisiae Proteins (genetics)</term><term>Saccharomyces cerevisiae Proteins (metabolism)</term><term>Sirolimus (pharmacology)</term><term>Transcription Factors (genetics)</term><term>Transcription Factors (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Agrégats de protéines (physiologie)</term><term>Facteurs de transcription (génétique)</term><term>Facteurs de transcription (métabolisme)</term><term>Microscopie confocale (MeSH)</term><term>Métallothionéine (génétique)</term><term>Prions (métabolisme)</term><term>Protéines de Saccharomyces cerevisiae (génétique)</term><term>Protéines de Saccharomyces cerevisiae (métabolisme)</term><term>Résistance des champignons aux médicaments (effets des médicaments et des substances chimiques)</term><term>Saccharomyces cerevisiae (métabolisme)</term><term>Sirolimus (pharmacologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Metallothionein</term><term>Saccharomyces cerevisiae Proteins</term><term>Transcription Factors</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Drug Resistance, Fungal</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Résistance des champignons aux médicaments</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteurs de transcription</term><term>Métallothionéine</term><term>Protéines de Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Prions</term><term>Saccharomyces cerevisiae</term><term>Saccharomyces cerevisiae Proteins</term><term>Transcription Factors</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de transcription</term><term>Prions</term><term>Protéines de Saccharomyces cerevisiae</term><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Sirolimus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Sirolimus</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Agrégats de protéines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Protein Aggregates</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Microscopy, Confocal</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Microscopie confocale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Prions are proteins that can exist under the same conditions in two or more conformations, at least one of them is infectious. Usually, acquisition of infectious prion conformation is associated with the formation of amyloids - protein aggregates with a characteristic spatial structure. About 10 prions have been identified in the yeast Saccharomyces cerevisiae. The Gln3 protein, which is one of the key regulators of nitrogen metabolism in S. cerevisiae, contains an amyloidogenic region manifesting prion-like properties. The prion properties of the full-length Gln3 have not been studied. We have found that the amyloidogenic region of Gln3 acts as a template and initiates aggregation of the full-length Gln3 in the presence of the [PIN<sup>+</sup>] prion when Gln3 is overexpressed. Full-length Gln3 in its aggregated form manifests prion-like properties, including infectivity and dependence on the anti-prion agents; however, unlike other known yeast prions, prion-like state of Gln3 is observed only upon the protein overproduction. Here, we suggest the term "conditional prions" for proteins, whose prion state is maintained exclusively under non-physiological conditions.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31228936</PMID><DateCompleted><Year>2019</Year><Month>06</Month><Day>26</Day></DateCompleted><DateRevised><Year>2019</Year><Month>06</Month><Day>26</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1608-3040</ISSN><JournalIssue CitedMedium="Internet"><Volume>84</Volume><Issue>4</Issue><PubDate><Year>2019</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Biochemistry. Biokhimiia</Title><ISOAbbreviation>Biochemistry (Mosc)</ISOAbbreviation></Journal><ArticleTitle>The Gln3 Transcriptional Regulator of Saccharomyces cerevisiae Manifests Prion-Like Properties upon Overproduction.</ArticleTitle><Pagination><MedlinePgn>441-451</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1134/S0006297919040126</ELocationID><Abstract><AbstractText>Prions are proteins that can exist under the same conditions in two or more conformations, at least one of them is infectious. Usually, acquisition of infectious prion conformation is associated with the formation of amyloids - protein aggregates with a characteristic spatial structure. About 10 prions have been identified in the yeast Saccharomyces cerevisiae. The Gln3 protein, which is one of the key regulators of nitrogen metabolism in S. cerevisiae, contains an amyloidogenic region manifesting prion-like properties. The prion properties of the full-length Gln3 have not been studied. We have found that the amyloidogenic region of Gln3 acts as a template and initiates aggregation of the full-length Gln3 in the presence of the [PIN<sup>+</sup>] prion when Gln3 is overexpressed. Full-length Gln3 in its aggregated form manifests prion-like properties, including infectivity and dependence on the anti-prion agents; however, unlike other known yeast prions, prion-like state of Gln3 is observed only upon the protein overproduction. Here, we suggest the term "conditional prions" for proteins, whose prion state is maintained exclusively under non-physiological conditions.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Antonets</LastName><ForeName>K S</ForeName><Initials>KS</Initials><AffiliationInfo><Affiliation>St. Petersburg State University, St. Petersburg, 199034, Russia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>All-Russia Research Institute for Agricultural Microbiology, St. Petersburg, 196608, Pushkin, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Belousov</LastName><ForeName>M V</ForeName><Initials>MV</Initials><AffiliationInfo><Affiliation>St. Petersburg State University, St. Petersburg, 199034, Russia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>All-Russia Research Institute for Agricultural Microbiology, St. Petersburg, 196608, Pushkin, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Belousova</LastName><ForeName>M E</ForeName><Initials>ME</Initials><AffiliationInfo><Affiliation>All-Russia Research Institute for Agricultural Microbiology, St. Petersburg, 196608, Pushkin, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nizhnikov</LastName><ForeName>A A</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>St. Petersburg State University, St. Petersburg, 199034, Russia. ant.nizhnikov@gmail.com.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>All-Russia Research Institute for Agricultural Microbiology, St. Petersburg, 196608, Pushkin, Russia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Biochemistry (Mosc)</MedlineTA><NlmUniqueID>0376536</NlmUniqueID><ISSNLinking>0006-2979</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C500769">CUP1-1 protein, S cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C071664">GLN3 protein, S cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011328">Prions</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D066329">Protein Aggregates</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D029701">Saccharomyces cerevisiae Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014157">Transcription Factors</NameOfSubstance></Chemical><Chemical><RegistryNumber>9038-94-2</RegistryNumber><NameOfSubstance UI="D008668">Metallothionein</NameOfSubstance></Chemical><Chemical><RegistryNumber>W36ZG6FT64</RegistryNumber><NameOfSubstance UI="D020123">Sirolimus</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D025141" MajorTopicYN="N">Drug Resistance, Fungal</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008668" MajorTopicYN="N">Metallothionein</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018613" MajorTopicYN="N">Microscopy, Confocal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011328" MajorTopicYN="N">Prions</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D066329" MajorTopicYN="N">Protein Aggregates</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012441" MajorTopicYN="N">Saccharomyces cerevisiae</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029701" MajorTopicYN="N">Saccharomyces cerevisiae Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020123" MajorTopicYN="N">Sirolimus</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014157" MajorTopicYN="N">Transcription Factors</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>6</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>6</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>6</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31228936</ArticleId><ArticleId IdType="pii">BCM84040587</ArticleId><ArticleId IdType="doi">10.1134/S0006297919040126</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Russie</li></country></list><tree><country name="Russie"><noRegion><name sortKey="Antonets, K S" sort="Antonets, K S" uniqKey="Antonets K" first="K S" last="Antonets">K S Antonets</name></noRegion><name sortKey="Antonets, K S" sort="Antonets, K S" uniqKey="Antonets K" first="K S" last="Antonets">K S Antonets</name><name sortKey="Belousov, M V" sort="Belousov, M V" uniqKey="Belousov M" first="M V" last="Belousov">M V Belousov</name><name sortKey="Belousov, M V" sort="Belousov, M V" uniqKey="Belousov M" first="M V" last="Belousov">M V Belousov</name><name sortKey="Belousova, M E" sort="Belousova, M E" uniqKey="Belousova M" first="M E" last="Belousova">M E Belousova</name><name sortKey="Nizhnikov, A A" sort="Nizhnikov, A A" uniqKey="Nizhnikov A" first="A A" last="Nizhnikov">A A Nizhnikov</name><name sortKey="Nizhnikov, A A" sort="Nizhnikov, A A" uniqKey="Nizhnikov A" first="A A" last="Nizhnikov">A A Nizhnikov</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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